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基因决定的循环乳糖酶/利津酸盐度和结肠直肠癌风险:一个双样本的孟德尔随机化研究

Sihao Han¹, Jiemin Yao¹, Hajime Yamazaki^2,3

¹Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.

|March 28, 2024

概括

高水平的乳酶-化酸酸酶 (LPH),一种参与牛奶消化过程的酶,与降低结直肠癌 (CRC) 风险有因果关系. 这一发现表明,LPH可能起到保护性作用,防止CRC的发展.

科学领域:

人类遗传学人类遗传学
癌症流行病学癌症流行病学
胃肠病学胃肠病学

背景情况:

牛奶消费与降低结肠直肠癌 (CRC) 风险有关,但潜在的机制尚不清楚.
乳糖化酶 (LPH) 是一种对牛奶消化至关重要的酶,它在CRC敏感性中的作用需要研究.

研究的目的:

使用孟德尔随机化 (MR) 方法调查LPH水平和CRC风险之间的直接因果关系.
分析LPH与CRC亚型的关联,特别是结肠和直肠癌.

主要方法:

采用了两个样本的门德尔随机化 (MR) 策略.
利用了来自芬兰研究的LPH遗传仪器以及来自FinnGen,PLCO Atlas和Pan-UK Biobank的CRC总结统计数据.
对cis变体 (rs4988235) 进行了初级MR分析和跨数据集的元分析,还对所有变体进行了分析.

主要成果:

分析显示,基因预测的LPH水平与整体CRC风险之间存在反向关联 (OR:0.92 [95%CI,0.89-0.95]).
升高的LPH水平与结肠癌 (OR:0.92 [95% CI,0.89-0.96]) 和直肠癌 (OR:0.92 [95% CI,0.87,0.98) 的风险降低有关.
在不同的分析方法和数据集中,结果一致.

结论:

基因预测的LPH水平表明与结直肠癌风险存在因果逆关系.
液性胰岛素可能作为对结肠癌和直肠癌的保护因素具有潜力.
需要进一步的研究来阐明具体的机制,并确认LPH在CRC预防中的作用.

关键词:

门德尔的随机化结肠直肠癌是什么意思乳糖酶/佛洛里津酸酶乳糖不持久性乳糖不持久性牛奶消化消化消化

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