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饮食和吸烟的烯胺和前列腺癌风险:CAPLIFE研究

Macarena Lozano-Lorca^1,2,3, Carlos Muñoz-Bravo^4,5, Rocío Barrios-Rodríguez^1,2,3

¹Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18016 Granada, Spain.

|March 28, 2024

概括

吸烟产生的烯胺可能会增加前列腺癌 (PCa) 风险,但饮食中的烯胺摄入量与PCa没有关联. 这项研究评估了与前列腺癌相关的饮食和烟草中的烯胺暴露.

科学领域:

毒理学和致癌的产生.
流行病学流行病学
营养科学营养科学

背景情况:

烯胺是一种可能的人类致癌物,存在于饮食和烟草烟雾中.
以前的研究还没有评估饮食和吸烟相关的烯胺暴露对前列腺癌 (PCa) 风险的综合影响.
了解这些暴露途径对于针对癌症预防的公共卫生干预至关重要.

研究的目的:

调查饮食中的烯胺摄入量与前列腺癌风险之间的关联.
评估吸烟导致的烯胺暴露与前列腺癌风险之间的关系.
评估这两个主要的烯胺暴露来源对PCa发病率的综合影响.

主要方法:

一项基于人口的病例控制研究 (CAPLIFE) 涉及428例PCa病例和393例对照.
使用经过验证的食物频率调查问卷收集详细的吸烟和饮食信息.
来自饮食和吸烟来源的烯胺摄入量的计算,用多变量逻辑回归和受限立方线模型对分析进行分类,分类为三位数.

主要成果:

在饮食中的烯胺摄入量与前列腺癌总体风险之间没有发现统计学意义上的关联 (调整后OR_T3vsT1=0.90).
对于吸烟导致的烯胺暴露,观察到显著的风险趋势 (p-trend = 0.032),最高暴露三位数显示PCa的几率增加 (调整后OR_T3vsT1 = 1.67).
限制立方线模型表明,与吸烟相关的烯胺暴露和PCa风险之间存在线性关系.

结论:

吸烟导致的烯胺暴露可能与前列腺癌的风险增加有关.
在这项研究中,在饮食中的烯胺摄入量和前列腺癌风险之间没有发现显著的关联.
需要进一步的研究,以阐明吸烟衍生的烯胺与前列腺癌发生有关的特定机制.

关键词:

烯胺的使用方法案例研究控制研究饮食饮食饮食饮食前列腺癌是前列腺癌.吸烟是为了吸烟.

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