基于维生素D代谢的维生素D状态的分类:高血压患者的随机对照试验
Sieglinde Zelzer1, Andreas Meinitzer1, Dietmar Enko1,2
1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Nutrients
|March 28, 2024
概括
低维生素D代谢物概况,称为"功能性维生素D缺乏症",没有预测维生素D补充剂对高血压患者的骨健康或心血管风险的益处. 需要进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 临床医学 临床医学
背景情况:
- 循环中的25-氧维生素D (25(OH) D是维生素D状态的标准指标.
- 24,25-二氧维生素D (24,25(OH) 2D) 与25(OH) D的比率 (维生素D代谢物比率,VMR) 可能表明维生素D的需求.
- 功能性维生素D缺乏症结合了低的25OH) D,低的24,25OH) 2D,以及低的VMR.
研究的目的:
- 要确定"功能性维生素D缺乏症"是否识别了那些从维生素D补充中受益的人.
- 评估维生素D补充剂对骨代谢和心血管风险的影响.
主要方法:
- 来自斯泰里亚维生素D高血压试验 (RCT) 的51名功能维生素D缺乏的参与者的分析.
- 参与者血清25(OH) D<75nmol/L,每天服用2800IU维生素D或安慰剂8周.
- 对副甲状腺激素 (PTH),骨标记物和心血管风险因素的评估影响.
主要成果:
- 维生素D补充剂没有改善功能维生素D缺乏症患者的骨代谢或心血管风险标志物.
- 观察到对副甲状腺激素 (PTH) 水平有显著影响.
- 观察了维生素D代谢物中预期的变化.
结论:
- 低维生素D代谢物概况 (功能性维生素D缺乏症) 不能确定那些从维生素D补充中受益于骨和心血管结果的患者.
- 功能性维生素D缺乏症的临床相关性需要在更大的随机对照试验中进一步调查.
相关概念视频
01:30Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K
01:23Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
01:18Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
01:28Special considerations while measuring blood pressure
722
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
722
01:15Antihypertensive Drugs: Thiazide-Class Diuretics
624
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
624
01:16Antihypertensive Drugs: Action of Diuretics
680
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
680