肠道微生物群与健康老龄人口的认知功能之间的相互作用:系统性审查
Maria Kossowska1, Sylwia Olejniczak1, Marcelina Karbowiak2
1Institute of Psychology, SWPS University, 03-815 Warsaw, Poland.
Nutrients
|March 28, 2024
概括
健康的老年人肠道微生物群的变化可能表明未来的认知能力下降. 改变的肠道细菌可能是痴呆症的早期迹象,在症状出现之前.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 与年轻人相比,健康的老年人表现出明显的肠道微生物群概况,有益细菌减少 (例如Bifidobacterium) 和增多的促炎微生物 (例如Enterobacteriaceae).
- 这些微生物变化与认知状态相关,但对它们对认知健康老年人群的影响的研究仍然有限.
研究的目的:
- 系统地审查有关肠道微生物群组成和健康老年人的认知功能之间的关系的现有文献.
- 在老年人的肠道微生物群中识别神经退行性疾病的潜在早期生物标志物.
主要方法:
- 在主要数据库 (PubMed, EBSCO, Web of Science, Scopus) 进行了全面的文献搜索,搜索到2024年3月之前发表的研究.
- 纳入标准侧重于对神经健康的老年人 (≥45岁) 的同行评审研究,评估肠道微生物群和认知功能,并使用Joanna Briggs Institute检查清单严格评估偏差风险.
主要成果:
- 确定了六项符合条件的研究,检查了肠道微生物群的分类构成和与认知功能相关的α多样性.
- 认知评估方法包括神经心理测试和生理测量,如脑电图 (EEG).
- 结果表明,特定细菌种群与认知功能之间存在不同的关联,基于分类层次 (系与家族) 的潜在差异.
结论:
- 老年人肠道微生物群的变化,即使没有被诊断出认知障碍,也可能代表阿尔茨海默病等疾病的早期生物标志物.
- 这些发现凸显了肠道微生物组作为临床前神经退行性变化的非侵入性指标的潜力.
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