较高水平的肥胖症与代谢功能障碍相关的肥胖性肝病在超重和肥胖症受影响的受试者进行非常低热量类饮食 (VLCKD) 八周后的较大减少有关
Annamaria Sila1, Sara De Nucci1, Caterina Bonfiglio2
1Center of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013 Bari, Italy.
Nutrients
|March 28, 2024
概括
非常低热量类饮食 (VLCKD) 有效地改善了代谢功能障碍相关的肝病 (MASLD) 以及超重和肥胖个体的相关肝脂肪. 在VLCKD干预8周后,更大的初始肥胖症严重程度与更好的结果相关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢功能障碍相关的肝病 (MASLD),以前是脂肪肝病,是一种与肥胖和代谢综合征相关的流行慢性肝病.
- 改变生活方式对于预防和管理MASLD至关重要.
- 非常低热量类饮食 (VLCKD) 在治疗MASLD和减少肥胖患者的肝肥胖症方面表现有前途.
研究的目的:
- 调查初始脂肪症严重程度对8周VLCKD干预措施改善肝脏脂肪和纤维化的疗效的影响.
- 在超重和肥胖个体接受VLCKD治疗后,评估人类参数和代谢生物标志物的变化.
主要方法:
- 一项涉及111名超重和肥胖参与者 (18-64岁) 的研究,他们接受了为期8周的VLCKD干预.
- 在干预前后评估人体测量,肝硬化 (通过CAP),肝硬化以及各种血液生物标志物 (包括HOMA-IR,脂质,葡萄糖,HbA1c和维生素D).
- 使用原始和多变量模型进行统计分析,以确定基线值与肝脏参数变化之间的相关性.
主要成果:
- 在VLCKD干预之前的肝脏肥胖症 (CAP) 和肝脏硬程度与干预后的相应变化之间观察到显著的正相关性.
- 在VLCKD干预导致显著减少的BMI,腰围,脂肪质量,血压,胰岛素耐药性 (HOMA-IR),胰岛素,HbA1c,禁食葡萄糖,总胆固醇,LDL和甘油三 (p <0.001).
- 在VLCKD干预后,维生素D水平显著增加 (p < 0.001).
- 患有更严重的初始肥胖症和纤维化症的受试者在8周的VLCKD后经历了更大的改善.
结论:
- 8周的VLCKD干预有效改善超重和肥胖个体的肝硬化和纤维化.
- 初始肝硬化和纤维化的程度会对VLCKD的治疗结果产生积极的影响.
- 在被研究的人群中,VLCKD显著改善了代谢健康标志物和身体成分.
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