时间限制的饮食和骨健康:通过元分析进行系统审查
Rubén Fernández-Rodríguez1, Miriam Garrido-Miguel1,2,3, Bruno Bizzozero-Peroni1,4
1Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain.
Nutrients
|March 28, 2024
概括
时间限制饮食 (TRE) 没有对成人骨健康产生负面影响,尽管它有减肥的好处. 需要更多的研究才能充分理解TRE.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 骨生理学 骨生理学
背景情况:
- 时间限制饮食 (TRE) 是一种饮食方法,将食物摄入量限制在每天的时间窗口内,通常用于减肥.
- 虽然TRE对脂肪组织的积极影响已有证据,但其对骨健康的影响在很大程度上仍未得到研究.
- 了解TRE对骨矿物质含量 (BMC),骨矿物质密度 (BMD) 和骨周转的影响至关重要.
研究的目的:
- 系统地审查和分析随机对照试验 (RCT),调查TRE对成人骨健康的影响.
- 综合当前关于TRE对BMD,BMC和骨周转标记物的影响的证据.
主要方法:
- 在PubMed,Scopus,Cochrane CENTRAL和Web of Science数据库中的系统文献搜索,截至2023年10月1日.
- 包括7个RCT,涉及313名成年参与者 (19-68岁),干预持续时间从4周到24周.
- 分析侧重于骨质量 (BMD);由于数据不足,不进行分析的BMC和骨周转指标.
主要成果:
- 七项研究中的五项报告显示,与对照组相比,TRE组的体重显著下降.
- 分析显示,TRE和对照组之间的骨矿物质密度 (BMD) 没有统计学上显著的差异 (p=0.328).
- 有限的数据阻止了骨矿物质含量 (BMC) 和骨周转指标的分析.
结论:
- 时间限制饮食 (TRE) 似乎对成年人骨健康结果没有不利的短期影响.
- 在本系统性审查中,TRE与对照条件相比没有对骨质量产生负面影响.
- 需要进一步的强大的RCT来最终评估TRE对骨健康,BMC和营业额的长期影响.
相关概念视频
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Essential Minerals for Bone Health
3.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.9K


