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脑损伤导致的创伤后应激障碍与谷氨酸摄入之间的关系:系统性审查

Benjamin F Gruenbaum¹, Alexander Zlotnik², Anna Oleshko³

¹Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.

|March 28, 2024

概括

饮食中的高谷氨酸摄入量与创伤性脑损伤 (TBI) 后发展创伤后应激障碍 (PTSD) 的可能性增加有关. 这表明饮食中的谷氨酸可能会影响创伤后PTSD的发展.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
营养科学营养科学

背景情况:

创伤性脑损伤 (TBI) 越来越多地与创伤后应激障碍 (PTSD) 相关.
连接TBI和PTSD的精确神经生物学机制仍然不清楚.
慢性谷氨酸神经毒性被假设为潜在的促成因素.

研究的目的:

系统地审查关于饮食中的谷氨酸酸消费与TBI后PTSD发病率之间的关系的现有文献.
调查饮食中的谷氨酸摄入量是否是TBI后PTSD发展的可修改风险因素.

主要方法:

系统的文献搜索确定了1748篇文章.
纳入标准用于选择44项相关研究进行分析.
统计分析以确定饮食中的谷氨酸酸水平与TBI后PTSD发展之间的关联.

主要成果:

来自高谷氨酸饮食的国家的人在创伤后出现PTSD的几率显著增加 (OR = 15.2,95% CI: 11.6919.76,p < 0.01).
在高饮食谷氨酸摄入量和TBI后PTSD风险增加之间观察到正相关性.

结论:

饮食中的高谷氨酸摄入量可能是创伤后PTSD发展的危险因素.
慢性谷氨酸神经毒性,可能由饮食驱动,可能在创伤后创伤后应激障碍的病理生理学中发挥作用.
需要进一步的研究,以探索饮食中的谷氨酸调节作为TBI后PTSD的预防或治疗策略.

关键词:

血脑屏障血脑屏障血脑屏障血脑屏障饮食饮食饮食饮食谷氨酸酸盐的使用方法创伤后应激障碍创伤后应激障碍创伤性脑损伤是一种创伤性脑损伤

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