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Updated: Jun 29, 2025

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
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Published on: August 17, 2019

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对AKT抑制剂的选择性研究和自由能量计算

Haizhen A Zhong1, David T Goodwin1

  • 1Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182, USA.

Molecules (Basel, Switzerland)
|March 28, 2024
PubMed
概括

开发选择性AKT抑制剂对于癌症治疗至关重要,以尽量减少副作用. 这项研究确定了AKT1和AKT3选择性的关键蛋白质残留物,可能减少与AKT2抑制相关的皮肤毒性.

关键词:
在 AKT AKT 里面.这是一种抗癌药物.同价对接对接是共价对接.药物设计 药物设计选择性的选择性

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