德尔塔-8-四大麻素的化学和药理学
Maged S Abdel-Kader1,2, Mohamed M Radwan2,3, Ahmed M Metwaly4
1Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Molecules (Basel, Switzerland)
|March 28, 2024
概括
德尔塔-8-四大麻 (Δ8-THC) 是一种受欢迎的大麻化合物,由于其稳定性和合成生产,它越来越受欢迎. 本综述涵盖了其提取,合成和分析,并比较了其与Delta-9-tetrahydrocannabinol (Δ9-THC) 的作用.
科学领域:
- 大麻素化学和药理学.
- 自然产品的合成和分析.
背景情况:
- 大麻sativa有很长的历史的人类使用经济和医疗目的.
- 德尔塔-9-四大麻 (Δ9-THC) 是大麻的主要精神活性成分,但由于副作用而受到限制.
- 较少的精神活性大麻素Delta-8-tetrahydrocannabinol (Δ8-THC) 正因其稳定性和易于合成而越来越受欢迎.
研究的目的:
- 审查D8-THC的提取,净化和结构阐明的方法.
- 讨论 Δ8-THC 的自然发生与合成起源.
- 介绍合成 Δ8-THC 的化学合成策略和杂质分析.
- 审查D8-THC的药理作用,并将其与D9-THC进行比较.
主要方法:
- 关于Δ8-THC提取,净化和合成的文献综述.
- 讨论用于检测市场上D8-THC产品中的杂质的分析技术.
- 对 Δ8-THC 和 Δ9-THC 的药理数据进行比较分析.
主要成果:
- 8-THC的合成越来越多,导致商业产品中的潜在杂质.
- 对于 Δ8-THC 的合成途径已经很成熟.
- Δ8-THC与CB1和CB2大麻素受体相互作用,与Δ9-THC相比表现出不同的药理特性.
结论:
- 由于其有利的特性,Δ8-THC提供了一个可能比Δ9-THC更安全的替代品.
- 确保合成 Δ8-THC 的纯度和准确分析对于消费者安全至关重要.
- 需要进一步研究 Δ8-THC 的治疗潜力和副作用概况.
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