包含硫化物衍生物的新型甲胺化合物被设计和合成为潜在的杀虫剂
Jingwen Wu1, Shuaihui Dang1, Yan Zhang1
1College of Resources and Environmental Engineering, Shanghai Polytechnic University, Shanghai 201209, China.
Molecules (Basel, Switzerland)
|March 28, 2024
概括
研究人员合成了新型含硫的甲胺杀虫剂,灵感来自Broflanilide. 几种化合物显示出对Plutella xylostella和Aphis craccivora的高杀虫活性,其中一种硫化物化合物需要进一步研究,以开发新的杀虫剂.
科学领域:
- 农业化学 农业化学
- 有机化学 有机化学
- 昆虫学 昆虫学是一门学科.
背景情况:
- 布罗夫拉尼利德是一种有效的甲胺杀虫剂,毒性低,对GABA受体没有交叉抵抗.
- 引入硫基可以使药物设计中的生物活性多样化.
研究的目的:
- 为了合成包含硫衍生物的新型甲基二胺化合物.
- 评估这些新化合物对关键农业害虫的杀虫功效.
主要方法:
- 合成12种含有硫化物衍生物的新型甲胺化合物.
- 使用点,1H NMR,13C NMR和HRMS进行结构确认.
- 对Plutella xylostella和Aphis craccivora进行杀虫剂活性评估.
主要成果:
- 大多数合成的化合物 (A-D) 在500毫克·L-1.1的剂量下实现了对P. xylostella和A. craccivora的100%杀伤性.
- 化合物C-2,C-3,C-4和D-2显示显著的杀虫活性 (60-100%) 对P. xylostella在0.625毫克·L-1.
- 特定化合物 (B-1,C-2,D-2,C-3) 对A.craccivora表现出高效,其中C-3 (硫化物) 化合物与母Broflanilide相比显示出更好的结果.
结论:
- 合成的硫化物含有甲胺化合物表现出强大的杀虫性能.
- 硫氧化物化合物C-3是开发新杀虫剂的有希望的候选物.
- 结构-活性关系分析为未来的杀虫剂研究提供了宝贵的见解.
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