抗炎和抗脂肪细胞功能障碍Ficus lindsayana的作用 乳和根源提取物
Jirarat Karinchai1, Pensiri Buacheen1, Daraphan Rodthayoy1
1Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Muang Chiang Mai, Chiang Mai 50200, Thailand.
Pharmaceuticals (Basel, Switzerland)
|March 28, 2024
概括
菲克斯林德赛纳根提取物 (FLRE) 有效地对抗脂肪细胞和巨细胞的炎症和胰岛素耐药性,为2型糖尿病预防提供了潜力. 这项研究强调了FLRE.
科学领域:
- 药理学和植物化学
- 代谢疾病研究研究
- 细胞生物学 细胞生物学
背景情况:
- 低度慢性炎症和脂肪细胞功能障碍是胰岛素抵抗和2型糖尿病 (T2DM) 的关键驱动因素.
- 肥胖加剧了这些情况,需要新的治疗策略.
- 传统医学经常利用*Ficus*种类的抗炎和抗糖尿病特性.
研究的目的:
- 为了研究*Ficus lindsayana*乳 (FLLE) 和根 (FLRE) 提取物的抗炎和胰岛素敏感作用.
- 评估这些提取物在减轻脂肪细胞中炎症诱导的胰岛素耐药性和巨细胞炎症方面的潜力.
- 为了比较FLLE和FLRE在解决与炎症和脂肪生成有关的关键分子通路中的有效性.
主要方法:
- 细胞毒性测定是在巨细胞,脂肪细胞和血液细胞 (PBMC,红细胞) 上进行的.
- 在FLLE和FLRE中总黄和含量的量化.
- 使用TNF-α诱导的脂肪细胞和LPS诱导的巨细胞进行体外研究,以评估抗炎和胰岛素敏感作用.
- 对炎症标记物 (iNOS,COX-2,IL-1β,IL-6,TNF-α,MCP-1) 和脂肪生成因子 (PPARγ,CEBPα) 的基因表达分析.
主要成果:
- 与FLLE相比,FLRE在巨细胞和脂肪细胞中表现出优异的抗炎活性.
- FLRE显著逆转了脂肪细胞中炎症诱导的胰岛素抵抗,改善了葡萄糖的吸收并抑制了脂解.
- 这两种提取物都减少了MCP-1的表达,并通过上调PPARγ和CEBPα促进了脂肪生成,而FLRE显著抑制了LPS诱导的NO生产和巨细胞中的关键炎症基因表达.
结论:
- 花根提取物 (FLRE) 显示出对抗炎症和与肥胖相关的胰岛素抵抗的显著潜力.
- FLRE调节炎症路径并促进脂肪生成的能力表明其作为治疗剂的实用性.
- 这些发现支持F. lindsayana根作为预防T2DM和相关代谢障碍的功能成分或补充剂的发展.
关键词:
菲克斯林德赛亚纳 (Ficus lindsayana) 是一个植物.脂质生成 (adipogenesis) 是一种慢性炎症是一种慢性炎症.胰岛素耐药性是一种胰岛素耐药性.代谢性疾病是代谢性疾病.更多相关视频
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