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侧面大脑管中的一个共同的神经元组合调节了小鼠的西普罗麻醉

Kang Zhou^1,2, Lin-Chen Zhang², He Zhu¹

¹Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Pharmaceuticals (Basel, Switzerland)

|March 28, 2024

概括

研究人员发现,侧面大脑管 (LHb) 中的特定神经元被麻醉剂siprofil激活. 调节这些神经元会影响从麻醉中出现,这表明在使用西普罗时控制意识的目标.

科学领域:

神经科学是一个神经科学.
麻醉学麻醉学
药理学药理学是指药理学的学科.

背景情况:

一般麻醉剂诱导失去意识 (LOC) 的机制尚未完全理解.
新型麻醉剂西普罗福 (Ciprofol) 提供快速发作和减少注射疼痛.
侧面大脑管 (LHb) 中的谷氨基神经元与其他麻醉剂的LOC调节有关.

研究的目的:

为了研究LHb神经元在西普罗诱导麻醉中的作用.
为了确定由西普罗激活的LHb神经元是否可以被向调节麻醉效应.

主要方法:

在活跃人群中进行有针对性的重组 (TRAP),以识别LHb中的西普罗激活神经元.
脑电图/肌电图记录和小鼠的正反射测试.
基因切除和化学遗传学用于操纵LHb中的神经元活动.

主要成果:

在LHb神经元中诱导c-Fos表达.
选择性切除或抑制西普罗激活的LHb神经元加快了麻醉后的出现,并减少了三角波活动.
这些神经元的激活延迟了出现,并诱导了更深层次的催眠.

结论:

由西普罗激活的LHb神经元在调节麻醉引起的意识丧失方面发挥着至关重要的作用.
针对这些特定的LHb神经元提供了一种潜在的策略,用于控制来自西普罗麻醉的出现.

关键词:

这就是TRAP TRAP.化学遗传学化学遗传学基因剥离基因剥离一般麻醉全身麻醉失去意识的意识丧失.

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