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Updated: Jun 29, 2025

Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs
05:11

Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs

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剂量预测和XZP-5610的药理动力学模拟,NASH治疗的小分子,使用全米缩放和基于生理的药理动力学模型

Lei Zhang1,2,3, Feifei Feng2,3, Xiaohan Wang2

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China.

Pharmaceuticals (Basel, Switzerland)
|March 28, 2024
PubMed
概括

这项研究成功地预测了FXR激动剂XZP-5610在人类中的药理动力学 (PK) 和肝脏度,使用全米缩放和PBPK建模. 这些预测支持在早期临床试验中选择安全有效的剂量.

关键词:
在XZP-561010中使用.测量尺度缩放 (allometric scaling) 是指所有米尺度缩放的方法.剂量方案 剂量方案预测肝脏度的预测基于生理学的药物动力学模型.

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