微针辅助通过皮肤输送卢拉西纳米颗粒
Ariana Radmard1, Ajay K Banga1
1Center for Drug Delivery Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Pharmaceutics
|March 28, 2024
概括
这项研究开发了一种新的微针贴片,用于通过皮肤输送卢拉西,克服了精神分裂症患者的坚持问题. 微针系统成功地在三天内提供治疗剂量,显示了改善药物管理的前景.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 神经科学是一个神经科学.
背景情况:
- 卢拉西是一种治疗精神分裂症的抗精神病药物,通常是口服的.
- 患者遵守每日口服药物是精神分裂症管理的一个重大挑战.
- 需要使用替代药物输送方法来改善治疗结果.
研究的目的:
- 开发和评估使用微针的通过皮肤输送卢拉西系统.
- 通过透皮途径实现为期三天的治疗效果.
- 为了克服被动扩散和化学增强剂的局限性,通过皮肤传递卢拉西.
主要方法:
- 生物降解的微针补丁阵列的制造使用Poly (乳酸-co-甘油酸) (PLGA) 纳米粒子.
- 通过溶剂蒸发,在PLGA纳米颗粒中封装卢拉西.
- 结合泡技术用于微针尖脱落和皮肤嵌入.
- 微针属性的表征,包括插入,机械强度和均性.
主要成果:
- 只有被动扩散和化学增强剂不足以有效地通过皮肤传递卢拉西.
- 开发的微针贴片成功地提供了相当于20毫克口服卢拉西的剂量.
- 微针显示出强大的机械性能和统一的阵列形成.
- 泡技术促进了微针脱落和留在皮肤中的过程.
结论:
- 通过微针技术通过皮肤输送卢拉西是可行的.
- 封装卢拉西纳米颗粒的微针贴片为精神分裂症治疗提供了一个有希望的替代方案.
- 这个系统解决了坚持挑战,并确保了长时间的药物输送.
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