氧化的口腔和口腔管理: "Oxipops"的发展
Dan Xu1, Chunmei Lan1, Juan Kou2
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
Pharmaceutics
|March 28, 2024
概括
通过口腔应用或药物糖果的口腔氧化素 (OT) 给药,为影响大脑和行为的鼻内输送提供了一个可行的替代方案. 这种方法尽管具有较低的生物可用性,但显示出类似的功能效果,突出显示了其治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 催产素 (OT) 是一个下丘脑神经,因其在社会认知,动机,减轻焦虑和缓解疼痛方面的作用而被广泛研究.
- 在社会功能障碍的疾病中,OT越来越被认为具有治疗潜力.
- 虽然鼻内注射是常见的,但通过血液度进行外周调解正在引起人们的注意.
研究的目的:
- 审查口腔粘膜中催产素的管理方法 (口腔应用,药物糖果),重点是提高血液度和的生物可用性.
- 通过检查对大脑和行为的功能影响来验证这些方法.
- 讨论口腔粘膜氧化的治疗优势及其对其他的更广泛应用.
主要方法:
- 开发新型的口腔粘膜输送系统,用于催产素:语言应用和药物糖 ("oxipops").
- 测量血中催产素度和评估生物可用性.
- 管理后对大脑和行为功能影响的评估.
主要成果:
- 口腔注射显著增加了血中催产素度和的生物可用性.
- 虽然鼻内注射产生了更高的血催产素水平,但口腔粘液的输送显示了与峰值度相比较的时间 (约. 30分钟) 和类似的功能效应.
- 估计的绝对生物利用率:~4.4%的口腔粘液对比11.1%的鼻内催产素.
结论:
- 氧化的口腔输入是有前途的替代途径,提供与鼻内输送相比较的功能结果.
- 这种方法绕过了胃肠道的降解,为类疗法带来了优势.
- 开发的"oxipops"和语言应用技术有可能在社会功能障碍障碍及其他疾病中进行临床应用.
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