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Updated: Jun 29, 2025

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通过连续双螺杆湿颗粒制造的受控释放配方的API分布研究:矩阵成型器,填充剂和工艺参数的影响

Phaedra Denduyver1, Chris Vervaet1, Valérie Vanhoorne1

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Pharmaceutics
|March 28, 2024
PubMed
概括

基甲基纤维素 (HPMC) 导致药物在颗粒中的分布不均. 这项研究确定了HPMC.

关键词:
内容的统一性 内容的一致性连续制造 连续制造有控制释放的释放.配方变量中的配方变量.基烯基甲基纤维素.过程变量是一个过程变量.双螺丝颗粒剂的颗粒化方法湿颗粒的湿颗粒化方法

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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