在体外和体外评估磁浮动剂型通过交替电流生物吸收计
Gustavo Serafim Rodrigues1, João Miguel Barboza1, Laís Pereira Buranello1
1Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, São Paulo, Brazil.
Pharmaceutics
|March 28, 2024
概括
这项研究表明,磁浮式药物递送系统 (MFDDS) 保持了胃的浮力. 交替电流生物悬浮计 (ACB) 系统在体外和体内有效地跟踪了MFDDS,证明了它对胃保留时间评估的实用性.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 浮式控制系统旨在延长固体剂型的胃保留时间 (GRT).
- 保持浮力而不改变胃排空是有效药物输送的关键.
- 磁浮式药物递送系统 (MFDDS) 为延长胃内宿提供了一个潜在的解决方案.
研究的目的:
- 在不同的生理条件下 (压力,粘度) 评估MFDDS.
- 为了评估MFDDS的性能,使用交替电流生物悬浮计 (ACB) 系统.
- 为了比较MFDDS在胃留方面的体外和体内性能.
主要方法:
- 在体外:MFDDS受压力 (760-1060 mmHg) 和粘度 (1-320 mPa·s) 测量浮动滞后时间 (FLT).
- 在体内:八名健康的志愿者在禁食和食状态下,使用ACB评估了GRT,FLT和口腔穿越时间 (OCTT).
- 用于追踪和成像MFDDS的交替电流生物悬浮计 (ACB) 系统.
主要成果:
- 在体外:压力,粘度和FLT显示了直接的相关性.
- 在体内:与空腹状态相比,在养状态下观察到增加的OCTT,GRT和FLT.
- 在这两种实验环境中,ACB系统在跟踪MFDDS方面都被证明是有效的.
结论:
- 该ACB系统是评估MFDDS在体外和体内的一种有价值的工具.
- MFDDS的性能受压力和粘度等生理因素的影响.
- 该研究验证了ACB用于监测胃中药物输送系统的使用.
更多相关视频
相关概念视频
Methods for Studying Drug Absorption: In vitro
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Measurement of Bioavailability: Pharmacodynamic Methods
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
In Vitro Drug Dissolution: Compendial Testing Models I
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Modified-Release Drug Delivery Systems: Bioavailability
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...


