通过超临界抗溶剂路线进行黄素/载体共降
Stefania Mottola1,2, Iolanda De Marco1,2
1Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Pharmaceutics
|March 28, 2024
概括
超临界抗溶剂 (SAS) 技术使用聚烯 (PVP) 和β-环氧 (β-CD) 载体产生增强的黄素 (CURC) 粉末. 与纯CURC相比,这些CURC/PVP和CURC/β-CD复合粉具有更好的溶解率.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
背景情况:
- 黄素 (CURC) 是一种强大的生物活性化合物,由于溶解性差,其生物利用性有限.
- 封装技术对于改善CURC等溶解不良药物的输送和疗效至关重要.
- 聚烯利 (PVP) 和β-环氧化 (β-CD) 是常见的载体,用于增强药物的溶解性和稳定性.
研究的目的:
- 使用超临界抗溶剂 (SAS) 技术合成含有黄素 (CURC) 的基于聚烯 (PVP) 和β-环氧化 (β-CD) 的复合粉末.
- 研究工艺参数 (压力,度,CURC/载体比) 对粒子形态和尺寸的影响.
- 评估SAS处理对CURC与PVP和β-CD溶解率和复杂化的影响.
主要方法:
- 超临界抗溶剂 (SAS) 技术用于沉CURC/PVP和CURC/β-CD复合粉末.
- 压力,总度和CURC/载体摩尔比率 (CURC/PVP和CURC/β-CD) 的系统变化在二甲基硫中.
- 福利埃变换红外 (FT-IR) 光谱和乔布法被用来描述CURC复合体并确定石化学.
- 准备的粉末的溶解概况与纯CURC.CURC.C.进行了比较.
主要成果:
- 对于PVP载体的最佳条件是:12.0 MPa,20 mg/mL度,以及1/2 CURC/PVP摩尔比率产生球形颗粒 (1.72 μm).
- 对于β-CD载体的最佳条件:9.0 MPa,200 mg/mL度和1/2或1/1的CURC/β-CD摩尔比率产生了明确的微米粒子 (2.98-3.69 μm).
- FT-IR分析证实了CURC在CURC/PVP和CURC/β-CD复合物中的存在.
- 乔布的方法表明,对于CURC/β-CD纳入复合体的形成,1/1的摩尔比率.
- 与纯CURC相比,SAS加工的粉末显示出明显改善的溶解率.
结论:
- 该SAS技术是有效的生产CURC/PVP和CURC/β-CD复合粉末与控制的形态和尺寸.
- 两种PVP和β-CD载体都提高了黄素的溶解率,表明生物可用性得到改善.
- 这项研究表明,SAS技术的潜力是开发先进的药物输送系统,用于像黄素这样的难溶化合物.
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