使用凝-花素合物颗粒作为乳化剂制备含有黄素的皮克林乳液,以作为生物灵感化品配方的潜在应用
Beena G Singh1,2, Nalin Bagora3, Minati Nayak1,2
1Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Pharmaceutics
|March 28, 2024
概括
研究人员使用生物相容的奇托和凝开发了一种新型的黄加载皮克林乳液. 这种绿色化品配方提供防晒和抗氧化剂的好处,增强皮肤护理应用.
科学领域:
- 化品科学 化品科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 生物相容的辅助剂在化品配方中越来越受青.
- 黄素提供紫外线吸收和抗氧化特性,可能提高护肤效果.
- 皮克林乳液为活性成分提供了一个稳定的输送系统.
研究的目的:
- 准备和表征黄素加载的皮克林乳液用于化品应用.
- 评估太阳保护因子 (SPF) 和配方的细胞吸收.
- 使用生物相容材料,如奇托和凝,以制造绿色乳液.
主要方法:
- 使用子油,黄素和β-碳甲基 (CMC) 和凝-A (GA) 的复合体颗粒制备充满黄素的皮克林乳液.
- 优化反应条件,包括材料比率,pH值,油分数和同质化速度.
- 使用动态光散射,泽塔电位,光学显微镜和体力学进行物理化学表征.
- SPF的确定和体外评估黄素吸收到纤维细胞.
主要成果:
- 优化的CMC-GA稳定皮克林乳液,油滴大小为100微米.
- 在4毫克/毫升的库尔库明负载下达到8.5的光谱光学SPF值.
- 在实验室中证明了黄素在纤维细胞 (WI26) 细胞中的成功吸收.
- 该配方表现出稳定性和理想的物理化学特性.
结论:
- 一种生物灵感的,绿色的皮克林乳液,装有黄素,成功地使用生物相容的辅助剂制备.
- 该配方由于其防晒和抗氧化能力,显示出对化品应用的潜力.
- 该研究强调了CMC-GA复合颗粒作为化品配方有效乳化剂的实用性.
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