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用米和米作为平板电脑滑剂的利用和评估
Ornanong S Kittipongpatana1,2, Karnkamol Trisopon1,2, Phanphen Wattanaarsakit3
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharmaceutics
|March 28, 2024
概括
大米和大米的显示承诺作为药片滑剂. 稳定脱脂大米 (sDFRB) 和大米 (RBW) 有效地降低了直接压缩片中的喷射力,RBW保持了片的硬度.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 农业科学 农业科学
背景情况:
- 平板滑剂对于直接压缩制造至关重要.
- 目前的酸酸等滑剂可能有缺点.
- 探索自然,可持续的替代品是非常有趣的.
研究的目的:
- 评估KJ CMU107大米中的稳定脱脂大米 (sDFRB) 和大米 (RBW) 作为潜在的平板滑剂.
- 评估它们在直接压缩过程中对平板电脑物理和机械性能的影响.
- 为了比较它们与商业酸 (MGS) 和化棉油 (HVO) 滑剂的有效性.
主要方法:
- 含有喷雾干燥大米粉 (SDRS) 的配方使用sFFRB,sDFRB或RBW作为滑剂进行制备.
- 使用直接压缩进行了药片注射.
- 评估的参数包括弹射力,重量变化,硬度,易碎性,分解时间和粉末流量.
主要成果:
- 与未滑对照组相比,所有经过测试的米衍生材料显著降低了药片喷射力.
- sDFRB (0.5-1.0%w/w) 可降低射出力高达80%,对硬度的影响最小.
- RBW (0.5%w/w) 有效地减少了82%的弹射力,同时保持了与HVO.com相比的平板电池强度.
结论:
- 稳定脱脂大米 (sDFRB) 在0.5-1.0%w/w时表现出有效的滑特性,对片的硬度有很小的影响.
- 米 (RBW) 是0.5%的高效滑剂,提供良好的平板强度和降低弹射力,而不会损害硬度.
- 无论是sDFRB还是RBW,都显示出开发的潜力,作为直接压缩片式配方的商业滑剂.
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