下一代益生菌作为改善人类健康的新疗法:当前趋势和未来前景
Mohamed E Abouelela1, Yosra A Helmy2
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Microorganisms
|March 28, 2024
概括
下一代益生菌 (NGP) 为慢性疾病提供了先进的治疗潜力,超越了传统的补充剂. 这些工程细菌对个性化医疗和新药开发有希望.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 下一代益生菌 (NGP) 是正在开发中的创新型有益细菌.
- NGPs的设计既适用于饮食和制药应用,显示慢性疾病的治疗前景.
研究的目的:
- 审查NGP的治疗潜力.
- 探索NGP研究轨迹,包括识别,描述和有针对性的交付.
- 阐明NGP对肠道健康,免疫功能和整体健康结果的影响.
主要方法:
- 对当前有关NGP的研究进行文献综述.
- 对NGP机制的分析,包括生物活性化合物生产和免疫调节.
- 识别和描述流行NGP菌株及其来源.
主要成果:
- 与传统益生菌相比,NGP提供了优势,使个性化疗法,合成生物学应用和有针对性的输送成为可能.
- 非政府组织通过竞争性排除病原体和强化肠道屏障等机制影响肠道健康,免疫功能和更广泛的健康结果.
- 确定了关键的NGP菌株及其来源,强调了它们的治疗潜力.
结论:
- NGPs代表了益生菌技术的重大进步,具有广泛的治疗应用.
- 对NGP机制和有针对性的交付的进一步研究将释放它们在先进疗法中的全部潜力.
- 政府非营利组织准备彻底改变各种慢性疾病的治疗方法,提高人类健康.
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