昆虫细菌 (Cutibacterium avidum):在假肢关节感染中是一种强大且被低估的病原体
Johanna Karlsson1,2, Nina Kamenska3, Erika Matuschek4
1NU Hospital Group, Department of Infectious Diseases, 461 73 Trollhättan, Sweden.
Microorganisms
|March 28, 2024
概括
Cutibacterium avidum是新出现的假肢关节感染 (PJIs) 的原因,挑战了以前的假设. 这项研究确定了四例部PJI病例,表明这种病原体可能被低估,并且比以前认为的更具毒性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 整形外科手术 整形外科手术
背景情况:
- 菌 (Cutibacterium avidum) 是最近发现的假肢关节感染 (PJIs) 的原因之一.
- 已经确定的原因,如Cutibacterium acnes,已经得到了充分的证据,特别是在肩膀关节修复手术中.
- 以前的报道将C. avidum PJIs与肥胖和特定的外科手术方法联系在一起.
研究的目的:
- 报告四例由C. avidum引起的部PJI病例.
- 从PJI病例中调查C. avidum菌株的遗传关系和抗生素敏感性.
- 评估与C. avidum PJI相关的临床表现和风险因素.
主要方法:
- 在30个月的时间里,四名患有由C. avidum引起的部PJIs的患者的回顾性病例系列.
- 全基因组测序以分析菌株相关性.
- 对抗生素敏感性测试以确定耐药性概况.
主要成果:
- 确定了四种不同的C. avidum菌株,排除了共同的爆发来源.
- 所有分离物完全易受测试的抗生素,缺乏已知的耐药基因.
- 患者在手术期间表现出明显的感染迹象,表明C. avidum的毒性.
- 确定的风险因素 (肥胖,直前切口) 不适用于这些病例.
结论:
- 四个病例的发生表明C. avidum可能是PJIs的新出现或被低估的原因.
- C. avidum在引起部PJIs方面表现出毒力.
- 对C. avidum PJI的典型风险因素可能不适用于所有人.
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