温度对卡巴酶编码等离子体转移在Klebsiella pneumoniae中的影响
Ji Woo Yang1, Ji-Hyun Nam1, Kwang Jun Lee2
1Division of Antimicrobial Resistance Research, National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28159, Republic of Korea.
Microorganisms
|March 28, 2024
概括
当地温度显著影响细菌的抗生素耐药性. 温暖的季节可能会促进碳烯酶基因的传播,突出显示温度.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 抗生素耐药性对人类健康构成越来越大的威胁.
- 温度等环境因素会影响细菌生长和基因转移.
- 关于局部温度变化与抗生素耐药性模式之间的联系的研究有限.
研究的目的:
- 调查局部温度对抗生素耐药性分布的影响.
- 分析碳酶生成肠道细菌 (CPE) 与温度有关的传播动态.
- 通过等离子体来确定碳烯酶基因转移的最佳温度.
主要方法:
- 利用来自韩国全球抗菌素耐药性监测系统 (2017-2021) 的数据.
- 分析了克莱布西拉肺炎对各种抗生素的抗生素耐药率.
- 在不同温度下进行结合实验,以评估等离子体的稳定性和转移.
主要成果:
- 抗生素耐药性率,包括卡巴烯,与局部温度有显著的相关性 (p < 0.047),除了氨基糖化物.
- 携带blaKPC和blaNDM基因的等离体的最佳结合温度分别为25°C和30°C.
- 特定的等离子体类型 (blaKPC-IncF,blaKPC-IncX3,blaNDM-IncX3) 在不同温度下表现出不同的稳定性,在25-30°C时普遍观察到更高的稳定性.
结论:
- 当地温度是影响抗生素耐药性传播的关键因素.
- 更高的环境温度可能会促进碳烯酶编码等离子体的传播.
- 了解依赖温度的基因转移对于控制CPE的传播至关重要.
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