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免疫抑制患者的宿主内部进化分析支持SARS-CoV-2病毒储库假说

Dominique Fournelle1,2, Fatima Mostefai1,2, Elsa Brunet-Ratnasingham3,4

  • 1Research Centre Montreal Heart Institute, Montréal, QC H1T 1C8, Canada.

Viruses
|March 28, 2024
PubMed
概括

免疫抑制患者可以发展SARS-CoV-2变种与免疫逃生突变,即使没有抗体治疗. 这项研究强调了病毒储库驱动变种演变和潜在的长期COVID联系.

关键词:
这就是SARS-CoV-2病毒.免疫逃生突变的突变人类遗传学是个学科.病毒基因组学 病毒基因组学

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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