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Updated: Jun 29, 2025

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
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Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

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用CRISPR/Cas9辅助基因组编辑来调节马匹疹病毒-1复制动力学在体外

Rabab T Hassanien1,2,3, Côme J Thieulent1,2, Mariano Carossino1,2

  • 1Louisiana Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.

Viruses
|March 28, 2024
PubMed
概括

在实验室中,CRISPR/Cas9基因编辑有效地抑制了马匹αherpesvirus-1 (EHV-1) 的复制. 用单指导RNA (sgRNAs) 向重要的EHV-1基因显示出对这种马类病毒的治疗潜力.

关键词:
这就是CRISPR/Cas9的作用.在EHV-1病毒中,这是一种抗病毒药物.马匹的阿尔法赫尔佩斯病毒-1基因编辑 基因编辑病毒复制病毒复制

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CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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