遗传性结缔组织疾病和急性后SARS-CoV-2的风险
Maggie L Bartlett1, Daniel Sova2, Mahim Jain3
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 212051, USA.
患有结缔组织疾病的患者面临严重COVID-19和发展COVID-19 (PASC) 后急性后果的更高风险. 提高意识和有针对性的研究对于这个弱势群体至关重要.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 类风湿病学 类风湿病学
背景情况:
- COVID-19对遗传性结缔组织疾病 (CTD) 患者的影响尚未得到充分了解.
- 临床观察表明需要调查CTD作为严重COVID-19结果的潜在风险因素.
- 在CTD患者中,COVID-19 (PASC) 后急性后果的患病率仍然未知.
研究的目的:
- 为了确定连接组织疾病是否是严重COVID-19,死亡和PASC的风险因素.
- 将CTD患者的疾病严重程度,死亡率和PASC率与一般住院队列进行比较.
- 评估CTD患者中PASC的患病率.
主要方法:
- 追溯审查来自JH-CROWN财团的数据.
- 国际疾病分类的分析,第10次修订 (ICD-10) 为住院队列的代码.
- 与CTD患者和整体队列之间的结局 (疾病严重程度,死亡,PASC) 的比较,包括糖尿病和高血压的子组.
主要成果:
- 一小部分但高比例的队列 (0.40%,63名患者) 患有结缔组织疾病.
- 与整个队列 (2.54%,p < 0.005) 相比,患有CTD的患者患PASC的比率显著更高 (9.52%).
- 住院队列中CTD的患病率高于一般人群,这表明风险增加.
结论:
- 结缔组织疾病可能是严重的COVID-19和PASC发展的独立风险因素.
- 需要提高医生和患者的意识,以提高CTD患者与COVID-19相关的风险.
- 进一步的研究是有必要的,以了解和减轻这些风险.
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