主体遗传背景影响BCG诱导的抗体与SARS-CoV-2尖端蛋白交叉反应
Aubrey G Specht1, Melanie Ginese1, Sherry L Kurtz2
1Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
接种Mycobacterium bovis Bacillus Calmette-Guérin (BCG) 疫苗可能会影响SARS-CoV-2的结果. 小鼠的遗传背景影响BCG诱导的对SARS-CoV-2尖端蛋白的交叉反应,这表明人类试验结果不一致的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 传染性疾病 传染性疾病
背景情况:
- 细菌卡尔梅特 - 盖林 (BCG) 疫苗可以预防结核病,并具有广泛的免疫效应.
- 早期的研究表明,BCG疫苗对SARS-CoV-2有保护作用,但后来的研究结果不一致.
- 遗传背景可能会影响BCG和SARS-CoV-2结果之间的观察到的关联.
研究的目的:
- 调查基因背景是否影响BCG疫苗接种和SARS-CoV-2结果之间的关联.
- 为了探索BCG和SARS-CoV-2尖端蛋白之间的潜在交叉反应.
主要方法:
- 在BCG和SARS-CoV-2尖端蛋白之间确定了共享的氨基酸序列.
- 在BCG疫苗接种的多样性外生的小鼠中测试了IgG与SARS-CoV-2尖端蛋白的交叉反应性.
- 在BCG疫苗接种多样性外生小鼠,BCG疫苗接种内生小鼠和未接种疫苗的小鼠中比较抗体水平.
主要成果:
- 来自一些BCG接种疫苗的多样性异种小鼠的血清与对照组相比,对SARS-CoV-2尖端蛋白的IgG交叉反应性更高.
- 在不同小鼠菌株之间观察到交叉反应的差异.
- 并非所有BCG疫苗接种的小鼠都表现出较高的交叉反应性IgG水平.
结论:
- 在人类研究中观察到的BCG疫苗接种和SARS-CoV-2结果之间的可变关联中,遗传背景可能是一个重要的因素.
- 需要进一步的研究来阐明BCG对SARS-CoV-2影响的机制性见解.
- 试点研究结果表明,遗传倾向可以解释不一致的临床试验结果.
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