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在Candida parapsilosis candidemia中与可纳抗性相关的危险因素:个案研究

Sabri Atalay¹, Derya Çağlayan², Eren Arkalı³

¹Department of Infectious Diseases and Clinical Microbiology, Tepecik Training and Research Hospital, Izmir, Turkey.

|March 28, 2024

概括

在Candida parapsilosis血流感染中,可纳的耐药性与腹腔内手术,低白蛋白水平以及在重症监护室之前使用可纳有关. 建议进行持续的监测和抗真菌管理.

科学领域:

传染性疾病传染性疾病
临床微生物学临床微生物学
关键护理医学关键护理医学

背景情况:

坎迪达菌种是重症监护室 (ICU) 中的主要入侵性病原体.
非白虫的Candida物种,特别是Candida parapsilosis (C. parapsilosis),越来越普遍.
在C. parapsilosis中,可纳耐药性构成了重大的临床挑战.

研究的目的:

为了确定与C. parapsilosis candidemia中富可纳抗性相关的因素.
在ICU患者中调查抗可纳的C. parapsilosis血流感染的预测因子.

主要方法:

一个案例研究设计,比较可纳耐药和可纳敏感的C. parapsilosis candidemia.
从2015-2021年在第三级医院收集的数据.
逻辑回归分析,包括向后消除,以确定独立的预测因子.

主要成果:

在177名患者中,有43%的人患有抗可纳的C. parapsilosis分离体.
单变量分析确定恶性瘤,免疫抑制治疗,腹腔内科手术,低albuminemia,以前使用可纳,和SOFA得分作为危险因素.
多变量分析显示腹腔内外科手术 (OR: 2.16),低albuminemia (OR: 2.56) 和以前使用可纳 (OR: 3.35) 作为独立预测因素.

结论:

腹腔内外科手术,低albuminemia和以前使用可纳与ICU中的可纳抗性C. parapsilosis候选症有显著的相关性.
对C. parapsilosis分离物和抗真菌耐药性的持续监测至关重要.
建议实施严格的感染控制和抗真菌管理计划.

关键词:

在Candida parapsilosis中使用.候选血病是什么意思候选血病是什么意思弗卢科纳尔 (Fluconazole) 是一种重症监护病房是重症监护病房.

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