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目前对胎盘增殖谱系障碍的病变发生的理解,重点是线粒体功能
Hiroshi Kobayashi1,2, Sho Matsubara2,3, Chiharu Yoshimoto2,4
1Department of Gynecology and Reproductive Medicine, Kashihara, Japan.
The journal of obstetrics and gynaecology research
|March 28, 2024
概括
冷胚胎移植 (FET) 周期显示胎盘增生谱 (PAS) 的风险增加,这是一个严重的妊娠并发症. 这篇评论探讨了PAS的发病过程,强调线粒体功能障碍是关键因素.
科学领域:
- 生殖医学和产科生殖医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 怀孕并发症的发病因子
背景情况:
- 辅助生殖技术 (ART) 的进步,包括玻璃化和卵巢刺激,已经普及了冷胚胎移植 (FET) 周期.
- 虽然FET周期通常比新鲜胚胎移植 (ET) 周期更好地产生体外受精结果,但它们与妊娠引起的高血压,孕前,胎盘增生谱 (PAS) 的风险增加有关.
- 危及生命的PAS的发病率正在全球上升,与剖腹产分娩率的增加并行.
研究的目的:
- 审查目前对胎盘增殖谱 (PAS) 病原学的理解.
- 讨论潜在的研究方向,以减轻与FET周期相关的PAS风险.
- 探索线粒体功能在PAS发展中的作用.
主要方法:
- 使用PubMed和谷歌学者数据库进行了全面的文献搜索.
- 该审查综合了有关风险因素,细胞通路和涉及PAS发展的分子机制的发现.
- 专注于确定线粒体功能与PAS病因之间的联系.
主要成果:
- 帕斯发病率与树叶缺陷,痕消失,异常的血管改造和异常侵入性热囊细胞有关.
- 结,解和激素替代等ART程序影响细胞通路,包括增殖,入侵,上皮细胞转移到介质酶 (EMT) 和线粒体功能.
- 涉及异常热原体迁移和EMT的分子在PAS胎盘中越来越多地被发现,并且经常参与线粒体生物发生和动态.
结论:
- 帕斯可能源于多因素的起源,涉及内在的倾向 (例如胎盘异常) 和环境触发因素 (例如缺陷的决定).
- 线粒体功能障碍被确定为PAS发展的潜在重要因素.
- 需要进一步研究ART,线粒体功能和PAS病原体之间的相互作用.
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