[异常的口服葡萄糖耐受性测试模式之间的关联在第二个三个月和怀孕年龄新生儿的大]
1Department of Obstetrics and Gynecology, Guangdong Maternal and Child Health Hospital, Guangzhou 511400, China.
Zhonghua fu chan ke za zhi
|March 28, 2024
概括
怀孕期间不正常的禁食血糖显著增加了新生儿怀孕年龄大 (LGA) 的风险. 禁食葡萄糖水平是预测LGA的关键指标,有助于临床风险评估.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 孕期糖尿病 (GDM) 查包括口服葡萄糖耐受性测试 (OGTT).
- 特定的OGTT异常模式可能会对妊娠结果产生不同的影响.
- 对于妊娠年龄来说很大 (LGA) 是一个与孕产妇和新生儿风险相关的显著周围并发症.
研究的目的:
- 评估第二个三个月中各种异常的75克口服葡萄糖耐受性测试 (OGTT) 模式与分娩大胎儿 (LGA) 新生儿的风险之间的关联.
- 确定不同OGTT时间点和LGA组合的预测值.
- 为了确定最佳的葡萄糖测量参数,用于LGA风险预测.
主要方法:
- 对66290名孕妇进行了一项回顾性队列研究.
- 根据OGTT结果 (正常,各种GDM模式) 将参与者分为8组.
- 使用多变量逻辑回归和ROC曲线分析来评估LGA风险和预测值.
主要成果:
- 显著增加的LGA风险被观察到在妇女与隔离异常的禁食葡萄糖 (GDM 0组),异常的禁食和1小时的葡萄糖 (GDM 0+1组),异常的禁食,1小时和2小时的葡萄糖 (GDM 0+1+2组).
- 所有测试的OGTT葡萄糖测量 (禁食,1小时,2小时及其组合) 都显示出LGA的预测价值.
- 与2小时葡萄糖相比,禁食血糖的LGA预测值更高,与其他组合相比没有显著差异.
结论:
- 特定的异常OGTT模式,特别是那些涉及高血糖的模式,与LGA的更高风险有关.
- 禁食血糖测量是临床实践中预测LGA的重要和潜在的最佳指标.
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:20Pathophysiology of Diabetes
926
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
926
01:27Glucose Transporters
22.7K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.7K
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
196
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
196
01:15Diabetes: Symptoms, Diagnosis, and Complications
530
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
530
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
174
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
174