双网络聚电解质的UV触发凝涂层,用于增强内皮质化
Xing-Wang Wang1,2, Yi-Jing Yin2, Jing Wang2
1Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 28, 2024
概括
一种新的水凝涂层加快左心房附属体 (LAA) 阻塞器的内皮化,减少与设备相关的血栓和抗凝剂的需要. 这项创新提高了LAA关闭装置的安全性和有效性.
科学领域:
- 生物材料科学 生物材料科学
- 心血管器械 心血管器械
- 医疗涂料 医疗涂料
背景情况:
- 左心房附属体 (LAA) 封闭器可以预防中风,但由于延迟内皮质化,容易发生与装置相关的血栓 (DRT).
- 复杂的结构和LAA封闭器的植入摩擦挑战了有效的表面涂层.
- 加速内皮质化对于改善LAA封闭器性能和患者结果至关重要.
研究的目的:
- 开发和评估一款用于LAA封闭器的新型水凝涂层.
- 为了增强血液相容性,并促进阻塞表面的快速内皮化.
- 为了减轻LAA关闭后与设备相关的血栓形成的风险.
主要方法:
- 双网聚电解质的in situ紫外线触发聚合,以创建水凝涂层.
- 纳入硫酸盐组用于血红相容性和Arg-Gly-Asp (RGD) 用于内皮促进.
- 在狗LAA封闭模型中评估涂层的机械性能和内皮质化.
主要成果:
- 双网水凝涂层由于静电相互作用而表现出优异的机械性能.
- 涂层显示了增强的血红相容性,并显著促进了内皮细胞的生长.
- 在犬模型中的体内研究表明,LAA封闭器的内皮质加速.
结论:
- 开发的水凝涂层有效地促进LAA封闭体的快速内皮质化.
- 这种功能性涂层有可能减少与设备相关的血栓并缩短术后抗凝剂.
- 这项研究提供了一种有希望的策略,以提高LAA关闭装置的临床安全性和有效性.
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