患有慢性肺阻塞性肺部疾病的患者甲状腺功能障碍的患病率和影响:系统性审查和元分析
Divine Besong Arrey Agbor1, Moulika Kari2, Rachel Chandra Harika Chukka3
1Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Cureus
|March 28, 2024
概括
甲状腺功能障碍 (TGD) 影响近一半的慢性阻塞性肺病 (COPD) 患者,甲状腺功能低下是最常见的. 需要进一步的研究来理解TGD.
科学领域:
- 肺部医学 肺部医学
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺功能障碍 (TGD) 是诊断为慢性阻塞性肺病 (COPD) 的患者的一种新出现的并发症.
- 了解COPD患者TGD的患病率和特征对于全面的患者护理至关重要.
研究的目的:
- 在慢性阻塞性肺病 (COPD) 患者中确定甲状腺功能障碍 (TGD) 的患病率.
- 评估TGD和COPD严重性指标之间的关联.
主要方法:
- 按照PRISMA指南进行了系统审查和元分析.
- 通过对PubMed,Embase和CINAHIL数据库的全面搜索,确定了相关的研究.
- 来自九项研究的数据被汇总在一起,以计算TGD的患病率,并比较TGD和无TGD患者之间的肺功能参数 (FVC,FEV1,PaO2,PaCO2).
主要成果:
- 在COPD患者中,TGD的综合患病率为45% (95%CI:25%至65%).
- 甲状腺功能低下症被确定为观察到的最常见的TGD类型.
- 在TGD和COPD严重程度或其他患者特征之间没有发现显著的关联.
结论:
- 甲状腺功能障碍在COPD患者中非常普遍,需要提高临床意识.
- 目前的数据没有将TGD与COPD严重程度联系起来,这表明需要进一步调查.
- 未来需要大规模的多中心前性研究来确定与COPD中TGD发展相关的临床因素和生物标志物.
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