血多不和脂肪酸与美国成年人抑郁症之间的关联
Man Wang1, Xiaofang Yan2, Yanmei Li2
1Department of Nutrition and Food Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China.
Frontiers in nutrition
|March 28, 2024
概括
血中某些多不和脂肪酸 (PUFA) 的较高水平,包括酸和酸,与美国成年人的抑郁症风险增加有关. 这一发现表明,PUFA可能是这种精神健康状况的潜在风险因素.
科学领域:
- 营养神经科学 营养神经科学
- 代谢精神病学 代谢精神病学
- 流行病学 流行病学
背景情况:
- 抑郁症显著影响功能能力,并造成巨大的社会成本.
- 以前关于血多不和脂肪酸 (PUFA) 与抑郁症之间的联系的研究产生了相互矛盾的结果.
研究的目的:
- 在美国成年人代表样本中调查n-3和n-6PUFA和抑郁症等离子体水平之间的关联.
主要方法:
- 从2011-2012年国家健康和营养检查调查 (NHANES) 中对2053名美国成年人 (年龄≥20岁) 的横截面分析.
- 测量了血PUFA水平,并使用患者健康问卷-9 (PHQ-9) 评估了抑郁状态.
- 采用二进制逻辑回归来检查PUFA四分位数与抑郁之间的关系,控制潜在的混因素.
主要成果:
- 血中甲基酸 (AA; 20:4n-6) 和多可沙特酸 (DTA; 22:4n-6) 的第三四分位数升高与抑郁症风险增加有关.
- 较高四分位数的多可萨氨酸 (DPAn-6; 22:5n-6) 和多可萨氨酸 (DPAn-3; 22:5n-3) 也与抑郁症有显著的关联.
- 在第二,第三和最高四分位数中,甲基酸 (AA) 与多可沙赫萨酸 (DHA) 的比率增加与抑郁症的可能性更大有关.
结论:
- 较高的特定PUFA的血度,即AA,DTA,DPAn-6和DPAn-3,可能代表美国成年人抑郁症的潜在风险因素.
- 血中的AA/DHA比率也可以作为抑郁风险的指标.
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