印度肝硬化病的病因谱:系统性审查和元分析
Shekhar Swaroop1, Manas Vaishnav1, Umang Arora1
1Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Journal of clinical and experimental hepatology
|March 28, 2024
概括
酒精是印度肝硬化的主要原因,酒精和NAFLD相关病例的增加趋势. 与病毒性肝炎相关的肝硬化正在下降,需要更新公共卫生策略和为肝病管理分配资源.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 肝硬化代表着全球严重的健康负担,对发病率和死亡率作出了重大贡献.
- 了解肝硬化病的特定病因格局和时间变化对于印度有效的公共卫生干预至关重要.
研究的目的:
- 系统地审查和对印度肝硬化病的病因谱进行元分析.
- 为了确定印度人口中肝硬化原因的变化趋势.
主要方法:
- 对电子数据库 (PubMed/Medline,Scopus,Embase) 进行了全面的搜索.
- 包括报告印度人口中肝硬化病因学的原始研究.
- 针对成人和儿童的各种病因,计算了聚合估计.
主要成果:
- 酒精是成年人肝硬化的主要原因 (43.2%),其次是非酒精性脂肪性肝病 (NAFLD) /密码性肝病 (14.4%),乙型肝炎病毒 (HBV) (11.5%) 和乙型肝炎病毒 (HCV) (6.2%).
- 与酒精有关的肝硬化显示出增长的趋势,与NAFLD/密码性原因一起,而病毒性肝炎病因显示出下降的趋势.
- 在儿童中,NAFLD/密码性 (22.3%) 和HBV (10.7%) 是主要确定的原因.
结论:
- 酒精仍然是印度成年人肝硬化的主要病因因素.
- 有一个明显的转向增加酒精和NAFLD相关的肝硬化,与病毒性肝炎相关的病例的同时下降.
- 这些发现对于制定健康政策和优化印度肝病管理资源配置至关重要.
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