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衰老对协会记忆中的编码/检索翻转的影响:fMRI证据来自偶然的应急学习
Else Schneider1, Marko Rajkovic2,3, Rudolf Krug4
1Center of Affective, Stress and Sleep Disorders (ZASS), University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Frontiers in aging neuroscience
|March 28, 2024
概括
老年人表现出关联性记忆检索受损和大脑活动模式的改变,特别是在前侧胰岛和后侧带带皮层. 这些编码/检索 (E/R) 翻转的变化可能表明神经早期衰老.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 衰老研究研究 衰老研究
背景情况:
- 关联性记忆对于情节性和语义性记忆至关重要.
- 与年龄相关的关联记忆的下降是认知衰老的标志,影响健康和病理衰老.
- 与年龄相关的关联记忆衰退的神经机制,特别是在偶然的学习中,仍然不清楚.
研究的目的:
- 调查衰老对偶发学习和记忆检索的脸部名称协会的影响.
- 使用fMRI检查编码/检索 (E/R) 翻转中的与年龄相关的变化.
主要方法:
- 在年轻 (N=23) 和老年 (N=22) 参与者中比较了面孔和名字对的偶然学习和记忆检索.
- 使用fMRI来评估神经活动和编码/检索 (E/R) 翻转.
主要成果:
- 与年轻的成年人相比,老年参与者表现出明显较差的检索性能.
- 年长的成年人显示在右侧前面的胰岛上有一个废除的E/R翻转.
- 在老年人后部中环皮质中观察到降低的E/R翻转激活幅度.
结论:
- 与年龄相关的关联记忆的下降与神经机制的改变有关.
- 在右前胰岛的E/R翻转神经调制受损可能是神经衰老的早期标志物.
- 这些发现有助于理解认知衰老和早期检测的潜在生物标志物.
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