在日本,对Efgartigimod治疗一般化肌痛严重症的治疗反应
Shigeaki Suzuki1, Akiyuki Uzawa1, Yuriko Nagane1
1Department of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.
在日本,Efgartigimod有效治疗了一般化肌痛性肌痛症 (MG) 患者,在各种MG亚型中显著改善了日常活动和生活质量. 治疗的灵活性允许广泛的患者选择和多样化的时间表.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 一般化肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛性肌痛
- 埃夫加蒂格莫德是一种FcRn抗剂,已被批准用于通用MG治疗.
- 日本对efgartigimod使用的真实数据有限.
研究的目的:
- 报告日本对一般性MG患者的efgartigimod临床实践使用情况.
- 在现实环境中评估efgartigimod的疗效和安全性.
- 评估不同泛性MG亚型的治疗反应.
主要方法:
- 日本肌痛性骨髓灰质炎登记处 (JAMG-R) 的调查确定了在2022年5月至9月期间开始使用efgartigimod的患者.
- 受访者被定义为在MG日常生活活动 (MG-ADL) 评分中获得≥2分的改善.
- MG复合物,MG-QOL15-r和安全性在26周内进行了评估.
主要成果:
- 36名患者 (2.7%) 开始服用efgartigimod,包括AChR+,MuSK+和血清阴性亚型;72%的人患有耐火性MG.
- 在第一个周期 (p<0.007) 后,MG-ADL,MG复合物和MG-QOL15-r的显著改善被观察到.
- 62%的患者是响应者,MuSK+患者的响应值得注意;治疗计划灵活.
结论:
- 在日本,Efgartigimod在广泛的一般性MG患者中有效且耐受良好.
- 灵活的治疗计划和患者选择是efgartigimod治疗的关键.
- 对于一般性MG患者,不达到最小的表现,可以考虑Efgartigimod.
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