工程瘤氧化纳米材料:促进癌症治疗的光动力疗法
Tingting Zuo1, Xiaodie Li2, Xuan Ma3
1College of Biological Sciences and Technology, Yili Normal University, Yining, China.
Frontiers in bioengineering and biotechnology
|March 28, 2024
概括
光动力疗法 (PDT) 使用光敏剂来产生杀伤瘤的活性氧物种 (ROS). 本综述探讨了能氧化瘤的纳米材料,克服缺氧以提高PDT癌症治疗疗效.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 纳米技术 纳米技术
背景情况:
- 光动力疗法 (PDT) 是一种使用光敏剂和光来产生细胞毒性活性氧物种 (ROS) 的癌症治疗方法.
- PDT提供了时空选择性和最小的侵入性,但受到低氧瘤微环境 (TME) 的阻碍.
- 缺氧显著降低PDT的疗效,因为它限制了ROS的产生.
研究的目的:
- 提供一个全面的回顾最近的进展,瘤氧化纳米材料增强PDT.
- 解决传统PDT中缺氧TME所带来的挑战.
- 探索改善PDT在癌症治疗中的临床应用的策略.
主要方法:
- 对基于纳米材料的瘤氧化策略的文献综述.
- 对现场O2生成,目标O2输送和通过光催化生成O2的方法的分析.
- 讨论诸如瘤血管正常化和线粒体呼吸调节等方法.
主要成果:
- 包括纳米材料在内的各种策略可以克服瘤缺氧,以提高PDT的疗效.
- 瘤氧化纳米材料提供了一种有希望的方法来增强低氧瘤中的ROS生成.
- 最近的发展着重于新材料和方法,以改善PDT的氧气供应.
结论:
- 克服瘤缺氧对于最大限度地提高PDT的有效性至关重要.
- 瘤氧化纳米材料是推动PDT的关键战略.
- 需要进一步的研究和开发,以将这些发现转化为改进的临床癌症治疗方法.
相关概念视频
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K