非HDL-C/apoB比率与一般人口的长期死亡率的关联:一个队列研究
Kerui Zhang1, Chenchen Wei1, Yaqing Shao1
1Center for Cardiovascular Disease, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, 215000, China.
Heliyon
|March 28, 2024
概括
非HDL-C/apoB比率可以预测一般人群的长期死亡风险. 较低的比率与增加全因和心血管死亡率有关,特别是在女性中.
科学领域:
- 心血管疾病研究研究
- 生物标志物发现发现
- 公共卫生 公共卫生
背景情况:
- 缺乏胆固醇的脂质颗粒通过非高密度脂蛋白胆固醇 (非HDL-C) 与阿波利波蛋白B (apoB) 的比率来表示.
- 这个比率是已知的心血管疾病风险指标.
- 它对一般人口长期死亡率的预测价值需要进一步研究.
研究的目的:
- 调查非HDL-C/apoB比率与所有原因的长期死亡率之间的关联.
- 探索非高血压-C/apoB比率与长期心血管死亡率之间的联系.
- 评估美国一般成年人群中非高密度胆固醇-C/apoB比率的预测潜力.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2005-2014) 的回顾性队列研究.
- 包括12,697名参与者,平均随访时间为68.0个月.
- 使用了卡普兰-梅尔曲线,日志级别测试,多变量考克斯回归和受限立方线模型.
主要成果:
- 总共记录了891例死亡 (7.0%) 和156例心血管死亡 (1.2%).
- 在经历死亡事件的参与者中观察到较低的非HDL-C/apoB比率.
- 非HDL-C/apoB比率独立预测了所有原因 (HR=0.51) 和心血管死亡率 (HR=0.33),女性有显著的相互作用.
结论:
- 非HDL-C/apoB比率显示了作为预测长期死亡率的生物标志物的潜力.
- 这种关联独立于已确定的心血管风险因素.
- 该比率的预测效用在临床实践中需要进一步考虑.
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