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Updated: Jul 10, 2026

Generation of Alginate Microspheres for Biomedical Applications
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使用超声波喷雾干燥改进了甲福明化-甲基酸盐 (MH-NaALG) 微球的合成

Anjana M1, Parag R Gogate1

  • 1Department of Chemical Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, India.

Heliyon
|March 28, 2024
PubMed
概括

超声波辅助喷雾干燥有效地产生了具有较小,均颗粒大小 (<10微米) 的梅特福林化微球. 这种新的方法提高了药物的溶解性和剂量,克服了传统方法的局限性.

关键词:
微球是微球的组成部分.操作参数 操作参数压力原子化压力原子化喷雾干燥 喷雾干燥超声波原子化的超声波.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...