评估乳糖补充剂对婴儿的影响:随机对照试验的系统审查研究方案
Anna Kozłowska-Jalowska1, Agata Stróżyk1, Andrea Horvath1
1Department of Pediatrics The Medical University of Warsaw Warsaw Poland.
JPGN reports
|March 28, 2024
概括
补充乳糖酶可能有助于控制婴儿,这是新生儿常见的疾病. 本系统性审查审查了使用乳糖酶治疗婴儿痛的有效性和安全性.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 基于证据的医学 基于证据的医学
背景情况:
- 婴儿是婴儿早期流行的一种功能性胃肠道疾病.
- 婴儿的确切原因尚未完全理解,但乳糖酶缺乏是潜在的促成因素.
- 目前关于饮食干预措施和乳糖补充剂治疗婴儿的证据有限.
研究的目的:
- 系统地审查口服乳糖酶补充剂在治疗婴儿结肠方面的有效性和安全性.
- 综合了婴儿的乳糖酶随机对照试验 (RCT) 的研究结果.
主要方法:
- 对比口服乳糖补充剂与安慰剂或没有干预的RCT的系统审查.
- 在Cochrane CENTRAL,MEDLINE和EMBASE中对患有的6个月以下婴儿进行的搜索.
- 使用Cochrane协作风险偏差工具评估的偏差风险 (第二版).
主要成果:
- 主要结局:响应者数量 (定义为减少每日哭泣).
- 二次结果:哭泣的持续时间/频率,婴儿的睡眠,父母的满意度,婴儿的不适,住院,生活质量和不良事件.
- 数据综合将集中于将乳糖补充剂与对照组进行比较.
结论:
- 该审查将提供关于乳糖酶补充剂在婴儿结肠发作中的有效性和安全性的证据.
- 结果将为临床实践和未来的研究方向提供信息,以管理婴儿.
- 结果将通过同行评审的出版物和会议演讲传播.
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