相关实验视频
Updated: Jun 29, 2025

02:26
Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
5.3K
静脉注射的S-胺在第三手术中的止痛效果. 一个随机的安慰剂控制的双盲临床试验
Lars B Eriksson1,2, Torsten Gordh1,3, Rolf Karlsten1,3
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
British journal of pain
|March 28, 2024
概括
高剂量的S-胺有效地减少了第三手术后24小时的术后疼痛. 这种预防性给予的止痛药也延迟了患者需要救援止痛药的需要.
科学领域:
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
- 在口腔外科手术.
背景情况:
- 在第三手术中,术后疼痛管理通常涉及降醇和易布洛芬.
- 阿片类药物通常用于严重的疼痛,但应避免在日间外科手术中使用.
- 止痛剂量S-胺是一种潜在的替代阿片类药物.
研究的目的:
- 为了评估预防性S-胺在第三手术后的术后疼痛管理中的有效性.
- 为了比较两种不同剂量的S-胺与安慰剂的影响.
主要方法:
- 进行了一项随机,安慰剂控制,双盲临床试验.
- 纳入了健康的成年受试者 (ASA I-II,18-44岁).
- 参与者接受高剂量 (0.25毫克/公斤),低剂量 (0.125毫克/公斤) S-ketamine,或安慰剂.
主要成果:
- 在手术后4小时,两组之间没有观察到疼痛评分 (VAS) 的显著差异.
- 在高剂量S-胺组中,在前24小时内注意到VAS得分的显著降低.
- 在高剂量S-胺组中,第一次救援药物的时间延长了12分钟.
结论:
- 在24小时内,S-胺0.25mg/kg的预防性施用显著减少了整体术后疼痛.
- 与安慰剂和低剂量S-ketamine相比,高剂量的S-ketamine延长了患者需要额外的止痛时间.
相关概念视频
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
410
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
410
Local Anesthetics: Clinical Application as Spinal Anesthesia
623
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
623
Local Anesthetics: Clinical Application as Epidural Anesthesia
430
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
430

