Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Translation01:31

Translation

14.8K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
14.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nocturnal Features and Daytime Characteristics in Narcolepsy: Reliability and Diagnostic Relevance for NT1 vs NT2.

Sleep·2026
Same author

Automated Deep Learning-Based Demyelination Load Segmentation in Metachromatic Leukodystrophy.

Clinical neuroradiology·2026
Same author

Intrathecal idursulfase-IT in children younger than 3 years with neuronopathic mucopolysaccharidosis II in a single-arm, open-label, phase 2/3 substudy and extension.

JIMD reports·2026
Same author

Intracerebral hemorrhage induces monocyte TNF signaling that is suppressed by Siponimod (BAF312): a single-cell transcriptomics study in patients.

medRxiv : the preprint server for health sciences·2026
Same author

Safety profile of idursulfase administered at home in patients with mucopolysaccharidosis II enrolled in the Hunter Outcome Survey.

Molecular genetics and metabolism·2026
Same author

Classification and clustering on nocturnal polysomnography: distinctions and overlaps between central disorders of hypersomnolence.

Sleep·2025

相关实验视频

Updated: Jun 29, 2025

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
08:33

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

13.3K

通过数量驱动的逆转译框架,推进神经病变亨特综合征的临床开发.

Robert D Latzman1, Olivia Campagne1, Meera E Modi1,2

  • 1Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, USA.

Clinical and translational science
|March 28, 2024
PubMed
概括

定量分析揭示了亨特综合征 (Mucopolysaccharidosis Type II;MPS-II) 中不同的认知轨迹. 早期的认知分数和生物标志物可以预测疾病的进展,有助于罕见疾病药物开发.

更多相关视频

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

10.7K
Purification of Transcripts and Metabolites from Drosophila Heads
12:49

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

21.9K

相关实验视频

Last Updated: Jun 29, 2025

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
08:33

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

13.3K
Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

10.7K
Purification of Transcripts and Metabolites from Drosophila Heads
12:49

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

21.9K

科学领域:

  • 神经科学是一个神经科学.
  • 罕见疾病 罕见疾病
  • 药物发现 药物发现 药物发现

背景情况:

  • 临床数据的定量评估加速了药物发现,但未得到充分利用,特别是在罕见疾病中.
  • 亨特综合征 (Mucopolysaccharidosis Type II; MPS-II) 是一种罕见的,X链接的溶酶体储存障碍,具有异质的认知进展.

研究的目的:

  • 概述临床开发中定量逆转换的框架.
  • 在MPS-II患者中描述认知轨迹的预测因素.

主要方法:

  • 使用来自138名MPS-II受试者 (年龄为2.5-10.1岁) 的数据,来自赞助和自然历史研究.
  • 应用混合效应模型来分析神经认知结果和疾病进展指标.
  • 根据年龄,认知状态和脑脊髓液糖氨基甘 (GAG) 生物标志物来精制目标人群.

主要成果:

  • 确定了特定的认知发展轨迹:最初的进展,平原 (4-8年),然后变量下降.
  • 在基线认知得分较低的受试者中观察到更快的认知衰退.
  • 在入学时发现加速下降与更高的脑脊液GAG水平相关.

结论:

  • 在MPS-II中神经认知过程因年龄,认知功能和入学时的生物标志物状况而异.
  • 这些发现对于设计MPS-II.II更有效的临床试验至关重要.
  • 定量框架支持改善罕见病药物开发.