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通过定制的非共价相互作用从细胞外矩阵衍生的基纳米纤维中控制释放药物
Haofu Huang1, Jeongmin Hwang2, Sudha Anilkumar2
1Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.
Biomacromolecules
|March 28, 2024
概括
弹性原纳米纤维 (ECnVs) 显示出药物输送的前景,有效地封装和释放各种小分子. 它们的可调节组合允许控制释放动力学和增强的原结合,以获得持续的治疗效果.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 弹性原纳米纤维 (ECnVs) 是具有可调节性质的生物相容纳米结构.
- 它们作为药物输送工具的潜力需要进行详细的调查.
研究的目的:
- 评估九种不同的ECnV配方,以评估它们的药物封装和释放能力.
- 评估ECnV组成和货物类型对药物加载和释放率的影响.
- 研究ECnVs的原结合亲和力和持续释放潜力.
主要方法:
- 生产类似弹性素的 (ELP) 和类似的 (CLP).
- 使用循环二重化 (CD),传输电子显微镜 (TEM) 和动态光散射 (DLS) 进行ECnV的表征.
- 药物封装和释放研究使用小分子 (德克萨米他,甲甲酸盐,多克索鲁比).
- 原结合测定和长期药物释放监测 (长达7天).
主要成果:
- ECnVs成功地封装并释放了各种小分子药物.
- 药物释放动力学受到货物的水性和ECnV组成的影响;疏水性药物释放速度较慢.
- ECnVs表现出显著的原结合能力和持续的药物释放长达7天.
结论:
- ECnVs代表了一种多功能药物输送平台,具有可调节的特性,用于控制释放.
- 它们的原结合能力表明,它们有可能在特定的组织中进行向的输送和长时间的保留.
- 这些发现支持为各种治疗应用开发基于ECnV的系统.
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