任务定网格单元发射被选择性地与成功的路径集成依赖行为相关联
Harry Clark1, Matthew F Nolan1
1Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, Hugh Robson Building, University of Edinburgh, Edinburgh, United Kingdom.
eLife
|March 28, 2024
概括
大脑中的网状细胞可能有助于导航. 当它们依赖路径集成时,它们对环境的定会提高性能,但当有视觉线索时,不会.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 空间导航 空间导航
背景情况:
- 网格发射场是空间定位或路径集成的假设神经基质.
- 区分这些角色需要调查与行为任务相关的电网单元发射.
研究的目的:
- 在位置记忆任务期间,研究小鼠中介性肠内皮层中网格和非网格细胞的发射模式.
- 为了确定网格单元发射是否与任务环境挂或独立编码距离.
- 评估网格细胞表示在不同提示条件下对行为做出的贡献.
主要方法:
- 记录了小鼠中介内皮层中网格和非网格细胞的激发.
- 使用位置记忆任务,使用不同的环境线索 (视觉线索存在或不存在).
- 分析了对任务环境和行为表现的网格细胞定之间的关系.
主要成果:
- 网格发射显示了与任务环境的可变定或独立编码的距离.
- 非网格电池的空间发射要么与网格电池连贯,要么稳定地与环境挂.
- 当视觉线索存在时,网格细胞定没有影响行为表现.
- 当在没有视觉线索的情况下将网格单元定在任务环境中时,性能得到了提高.
结论:
- 网格单元定到任务参考框架可以在需要路径集成时选择性地提高性能.
- 当外部线索可用时,网格单元格表示对于位置编码并不必不可少.
- 研究结果表明,网格细胞在空间认知和导航中的作用取决于环境.
相关概念视频
Fixed Action Patterns
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
Cell Migration
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
Cytoskeletal Coordination in Cell Migration
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
Propagation of Action Potentials
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...


