酸的使用和甲状腺风暴患者的结果:一项观察性研究
Yuichiro Matsuo1, Atsushi Miyawaki1,2, Hideaki Watanabe1
1Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, 113-8655, Japan.
The Journal of clinical endocrinology and metabolism
|March 28, 2024
概括
早期酸 (KI) 可能降低甲状腺风暴患者的死亡率. 这项研究发现,使用KI可减少住院时间和成本.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 临床指南建议用于甲状腺风暴的抗甲状腺药物与一起服用.
- 在甲状腺风暴管理中的特定疗效尚未得到充分证实.
研究的目的:
- 调查早期酸 (KI) 给药与甲状腺风暴患者的住院死亡率之间的关联.
- 分析KI对住院时间和住院费用的影响.
主要方法:
- 日本诊断程序组合数据库的回顾性分析 (2010年7月-2022年3月).
- 在入院后2天内接受KI的患者与没有接受KI的患者之间的住院死亡率,住院时间和成本的比较.
- 对患有格雷夫斯病和没有格雷夫斯病的患者进行了子组分析.
主要成果:
- 在3188名患者中,2350人接受了早期KI. 原始死亡率为6.1% (KI组) 和7.8% (非KI组).
- 调整后的分析显示,KI与整体死亡率 (OR,0.91) 之间没有显著的关联.
- 在Graves病患者中,KI与较低的死亡率相关 (OR,0.46). 在非Graves病患者中没有观察到显著差异 (OR, 1.11).
- KI组住院时间较短,总住院费用较低.
结论:
- 酸 (KI) 可能降低诊断为格雷夫斯病的甲状腺风暴患者的住院死亡率.
- 早期使用KI与减少住院时间和住院费用有关.
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