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代谢物,健康的生活方式和与上胃肠道癌症相关的多基因风险评分:来自英国生物银行研究的发现
Shuting Li1,2, Jiajing Che1,2, Bingbing Gu1,2
1Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Journal of proteome research
|March 28, 2024
概括
代谢物在检测上部胃肠道 (UGI) 癌症方面表现有希望,特别是在那些不健康的生活方式或高遗传风险的人群中. 这项研究强调了它们对UGI癌症歧视的临床意义.
科学领域:
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 之前的代谢学研究已经确定了上部胃肠道 (UGI) 癌症的预测代谢物.
- 然而,生活方式和遗传风险对UGI癌症中的血代谢物的影响在很大程度上尚未被探索.
研究的目的:
- 研究生活方式和遗传风险在UGI癌症背后的代谢机制中的作用.
- 评估代谢物,生活方式因素和UGI癌症检测遗传风险评分的区分能力.
主要方法:
- 鉴定了与UGI癌症相关的差异性代谢物,使用部分最小平方区分分析和威尔科克森测试.
- 参与者计算的健康生活方式指数 (HLI) 和多基因风险评分 (PRS).
- 对比了代谢物,HLI和PRS模型的诊断性能,包括基于生活方式和遗传风险的子组分析.
主要成果:
- 确定了15种UGI癌症相关的差异代谢物.
- 代谢物模型 (AUC=0.699) 的表现优于HLI (AUC=0.615) 和PRS (AUC=0.593) 模型.
- 代谢物模型在不健康的生活方式 (AUC=0.783) 和高遗传风险 (AUC=0.770) 的个体中表现出优异的歧视.
结论:
- 代谢生物标志物对于UGI癌症歧视具有显著的临床价值.
- 代谢物概况在识别不健康的生活方式和高遗传倾向的个体中的UGI癌症方面特别有效.
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