增强慢性炎症和增加分支链氨基酸在上腺疾病:一个横截面研究
Annop A Kittithaworn1, Prerna Dogra1,2, Jasmine Saini1
1Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
The Journal of clinical endocrinology and metabolism
|March 28, 2024
概括
上腺疾病,包括功能和非功能上腺质量,与更高的糖蛋白乙化 (GlycA) 和分支链氨基酸 (BCAA) 相关,表明心血管风险和死亡率增加.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 心血管健康 心血管健康
背景情况:
- 过多的上腺激素与心血管 (CV) 风险和死亡率的增加有关.
- 了解上腺疾病对代谢的影响对于风险分层至关重要.
研究的目的:
- 研究各种上腺疾病对特定生物标志物的影响.
- 评估炎症标志物糖蛋白乙化 (GlycA),分支链氨基酸 (BCAA),体和肠道微生物组代谢物 (TMAO,贝他因).
主要方法:
- 一个单一中心的横截面研究包括802名上腺质量患者和5241名参考个人.
- 使用核磁共振光谱学测量了GlycA,BCAA,体,TMAO和贝他因.
- 多变量后勤分析根据主要的人口和临床因素进行了调整.
主要成果:
- 与参考组相比,所有患有上腺质量的患者群体都显示GlycA增加.
- 在非功能性腺瘤 (NFAs),轻度自主皮质醇分泌 (MACS),库辛综合征 (CS),原发性阿尔多斯特隆症 (PA) 和上腺皮质癌 (ACC) 中观察到升高的BCAA.
- 其他代谢物显示出不同的关联,在调整和子组分析后,结果一致.
结论:
- 功能和非功能上腺质量与增加的GlycA和BCAA有关.
- 这些生物标志物与不良的心脏代谢疾病和死亡率有关.
- NFAs表现出与MACS和CS相似的代谢特征,这表明它们有共同的病理生理路径.
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