头癌患者的抑郁症状,全身炎症和生存率
Elizabeth Cash1,2, Christy Albert1, Iona Palmer3
1Department of Otolaryngology-Head and Neck Surgery and Communicative Disorders, University of Louisville School of Medicine, Louisville, Kentucky.
JAMA otolaryngology-- head & neck surgery
|March 28, 2024
概括
头癌患者的抑郁症与炎症有关,这会影响生存. 解决抑郁症可能会改善治疗反应和结果.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 头癌患者的抑郁率很高.
- 抑郁症和炎症与癌症有关,可能会影响生存率.
- 炎症可能会调解抑郁症对头癌结果的影响.
研究的目的:
- 研究治疗前抑郁症状,炎症和瘤反应对头癌患者整体存活率的调解途径.
- 评估抑郁和炎症如何影响生存结果.
主要方法:
- 预期的观察性队列研究.
- 包括394名头癌患者.
- 评估了抑郁症状 (PHQ-9),系统性炎症 (SII),瘤反应和2年整体存活率.
主要成果:
- 抑郁症状与较高的炎症有关 (部分r = 0.168).
- 抑郁症 (HR = 1.04) 和炎症 (HR = 1.36) 都预测了死亡率.
- 炎症完全介导了抑郁症与生存的联系;瘤反应部分介导了它.
结论:
- 系统性炎症是连接抑郁症与头癌死亡率的关键机制.
- 解决抑郁症,即使是轻微的症状,对于改善治疗反应和生存至关重要.
- 抑郁症是临床干预治疗头癌症的可行目标.
更多相关视频
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Stress and Mental Health
155
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
155
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Inflammatory Bowel Disease II: Crohn's Disease
233
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
233


