外源性雌激素在头癌的发展中的作用
Christian Doll1, Elena Hofmann1,2, Robert Preissner3
1Department of Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
JAMA otolaryngology-- head & neck surgery
|March 28, 2024
概括
口服避孕药 (OC) 的使用与年轻女性头癌 (HNC) 的风险更高有关. 绝经后的激素替代疗法 (HRT) 与老年女性中HNC的风险较低有关.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 头癌 (HNC) 发病率中的性别差异表明性激素的作用.
- 外源性雌激素暴露是HNC发展的潜在因素.
研究的目的:
- 调查外源性雌激素暴露与女性患者头癌 (HNC) 风险之间的关联.
- 评估口服避孕药 (OC) 使用和激素替代疗法 (HRT) 对HNC发育的影响.
主要方法:
- 一项大型的多中心队列研究利用了TrinetX现实世界数据库,分析了20年的临床记录.
- 女性患者根据OC使用 (年龄18-45岁) 和HRT使用 (年龄≥50岁) 被分为年龄分层的队列.
- 倾向性得分匹配被用来控制包括年龄,酒精和尼古丁依赖在内的混因素.
主要成果:
- 使用口服避孕药 (OCs) 的女性显示HNC诊断的风险增加了47% (RR, 1.47;95% CI, 1.21-1.78).
- 使用绝经后激素替代疗法 (HRT) 的女性显示,HNC诊断的风险降低了23% (RR,0.77;95% CI,0.64-0.92).
结论:
- 研究结果表明,口服避孕药使用与HNC风险之间存在积极联系.
- 在使用激素替代疗法和HNC风险之间观察到负相关性.
- 需要进一步研究详细的生殖健康数据,以澄清外源性雌激素在HNC中的作用.
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