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设计和开发一个非侵入性的眼压估计器

Siddharth K Karthikeyan¹, Swaminathan M Sundaram, Ramesh S Ve¹

¹Department of Optometry, Manipal College of Health Professions (MCHP), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.

Optometry and vision science : official publication of the American Academy of Optometry

|March 28, 2024

概括

这项研究开发了一种新型的眼压估计器 (OPE),用于在闭眼时可靠的,非侵入性的眼内压 (IOP) 监测. OPE准确地测量了IOP波动,这对于格洛科马治疗至关重要.

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
医疗器械医疗器械

背景情况:

瞬间眼内压力 (IOP) 测量不足以检测IOP峰值和波动,特别是在睡眠期间.
内皮压的变化显著影响着青光眼的进展,需要持续监测以了解动态内皮压的变化.

研究的目的:

设计和验证一种新的眼压估计仪 (OPE),用于在闭眼条件下准确,非侵入性地测量眼压.
通过实现持续的,动态的IOP评估来解决当前IOP监测方法的局限性.

主要方法:

开发了一种使用压力传感器和可压缩隔膜的OPE,以测量通过模拟眼传输的IOP.
在去核的山羊眼球和尸体眼睛上验证了OPE,并将测量结果与反弹计进行了比较.
在10只眼睛中,诱导和记录的IOP在10分钟间隔内从3到30mmHg不等.

主要成果:

OPE测量显示,与3至30mmHg之间的诱导IOP有线相关性.
该设备表现出卓越的可靠性 (类内相关系数=0.998) 和可重复性.
诱导IOP和OPE测量之间的平均差异是最小的 (0.22 ± 3.50 mmHg).

结论:

眼压估计器 (OPE) 提供了一种可靠和准确的方法,用于在闭眼状态下进行非侵入性IOP测量和波动监测.
这项技术有望通过动态IOP评估来改善青光眼的管理.

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